FC 121THE UPTAKE OF PET RADIOTRACER 18 F-FLUORODEOXYGLUCOSE BY THE RENAL ALLOGRAFT SIGNIFICANTLY CORRELATES WITH THE ACUTE BANFF SCORES OF CORTEX INFLAMMATION

Abstract Background and Aims Acute T-cell mediated rejection (TCMR) is associated with the recruitment of mononuclear leukocytes into renal transplant, which corresponds to core conventional Banff classification. The boosted metabolism these inflammatory cells can be assessed by positron emission tomography (PET) quantifying uptake 18F-fluorodeoxyglucose (18FDG). correlation biopsy-based versus PET-based scores acute inflammation in transplant unknown. Method From January 2013 December 2019, we prospectively performed 114 18FDG-PET/CT 105 adult KTR who underwent per cause biopsy for suspected TCMR. Biopsy-proven polyoma-BK nephropathies (n=7) uninterpretable PET images (n=2) were excluded. PET/CT was 194±19 minutes after administration 243±35 MBq 18FDG, before any immunosuppression change. mSUVs measured both upper lower poles allograft. score conventionally defined as sum (from 0 15) g (glomerulitis), ptc (peritubular capillaritis), t (tubulitis), i (inflammation non-scarred cortex) v (endarteritis). “total i” 3) total cortical inflammation, including scarred cortex. Regression mSUV against performed, Pearson coefficients calculated. distribution between groups non-parametric Kruskal-Wallis test followed Dunn’s post hoc test. Results mean age cohort 51.5±14.3 years, M/F ratio 67/38. prevalence biopsy-proven TCMR borderline 20.9% 16.2%, respectively. 105-case 1.82±0.45. highest value 12, while 55.2% biopsies scored 0. “Total was: (58.8%); 1 (20.6%); 2 (8.8%); 3 (11.8%). showed a significant (p<0.0001), adjusted R² 0.38. significantly different subgroups (p, 0.0047), 2.33±0.76 1.68±0.24 1. Conclusion may help noninvasively assess degree allograft